We validated the impact of acetylcholine at network level using available data from literature. As in the experiments, we observe different network dynamics depending on the concentration of acetylcholine.
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M-type (12)
SLM_PPA
SO_BP
SO_BS
SO_OLM
SO_Tri
SP_AA
SP_BS
SP_CCKBC
SP_Ivy
SP_PC
SP_PVBC
SR_SCA
E-type
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Concentration (10)
[ACh] = 0μM
[ACh] = 1μM
[ACh] = 5μM
[ACh] = 10μM
[ACh] = 20μM
[ACh] = 50μM
[ACh] = 100μM
[ACh] = 200μM
[ACh] = 500μM
[ACh] = 1000μM
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Spike Time
Mean Firing Rate
Traces
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Spike Time
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Mean Firing Rate
Distribution of neuron firing rate. We excluded first 1000 ms and sampled a maximum of 100 random neurons*.
No data available.
[*] We may see an empty mean firing rate plot, even though there are spikes in the network (see Spike Time section). This is because the plot is based on a sample of 100 neurons, none of which may spike at low firing rates.