Acetylcholine

Experimental Data

Acetylcholine (ACh) is one of the most studied neuromodulators, particularly important for the hippocampus. Like other neuromodulators, its effect on the network can span several time and space scales. Here, we report the effect of ACh on resting membrane potential, firing rate, synaptic function, and network activity.

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Resting membrane potential

Firing rate

Synapse

Network

Resting membrane potential

The data below shows that ACh tends to increase the resting membrane potential of CA1 neurons.

Firing rate

The data below shows that ACh tends to increase the firing rates of CA1 neurons.

Synapse

The data below shows that ACh tends to increase the postsynaptic response (potential or current) in CA1.

Network

Consistent with the effect on neurons and synapses, ACh tends to increase the network activity, which in turn induces oscillations.