Resources

Network model

The model of the full CA1 can be downloaded from Harvard dataverse.

Code

Github repository with the code for the figures of the manuscript Romani et al. (2024).
github.com/BlueBrain/rat_ca1_model_code/

Simulating a Hippocampus Microcircuit

A massive open online course (MOOC) about the CA1 microcircuit.
edx.org/learn/neuroscience/ecole-polytechnique-federale-de-lausanne-simulating-a-hippocampus-microcircuit

Publications

• Romani et al. Community-based Reconstruction and Simulation of a Full-scale Model of Region CA1 of Rat Hippocampus. BioRxiv.
  https://www.biorxiv.org/content/10.1101/2023.05.17.541167v2
• Bologna L.L., Tocco A., Smiriglia R., Romani A., Schürmann F., Migliore M. (2023). Online interoperable resources for building hippocampal neuron models via the Hippocampus Hub. Front Neuroinform. 2023 Nov 1:17:1271059. doi: 10.3389/fninf.2023.1271059. eCollection 2023.
• Romani A., Schürmann F., Markram H., and Migliore M. (2022). Reconstruction of the Hippocampus. Adv. Exp. Med. Biol. 1359, 261–283. 10.1007/978-3-030-89439-9_11.
• Sáray S., Rössert C.A., Appukuttan S., Migliore R., Vitale P., Lupascu C.A., Bologna L.L., Van Geit W., Romani A., Davison A.P., et al. (2021). HippoUnit: A software tool for the automated testing and systematic comparison of detailed models of hippocampal neurons based on electrophysiological data. PLoS Comput. Biol. 17, e1008114. 10.1371/journal.pcbi.1008114.
• Ecker A., Romani A., Sáray S., Káli S., Migliore M., Falck J., Lange S., Mercer A., Thomson A.M., Muller E., Reimann M.W., Ramaswamy, S. (2020). Data-driven integration of hippocampal CA1 synaptic physiology in silico. Hippocampus. 2020 Nov;30(11):1129-1145. doi: 10.1002/hipo.23220. Epub 2020 Jun 10.
• Migliore R., Lupascu C.A., Bologna L.L., Romani A., Courcol J.-D., Antonel S., Van Geit W.A.H., Thomson A.M., Mercer A., Lange S., et al. (2018). The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow. PLoS Comput. Biol. 14, e1006423. 10.1371/journal.pcbi.1006423.