Reconstruction Data

Acetylcholine

Using data from literature, we derive a dose-effect behavior of a tonic application of ACh on neurons and synapses.

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Neurons
Synapses
Neurons

The net effect of ACh on CA1 neurons results in a depolarising current. The dose-effect relationship can be described with a Hill function.

  • • Experimental data
  • ― Fit
  • - - Extrapolated
Synapses

The net effect of ACh on CA1 synapses results in an increase of the initial release probability (i.e. U parameter of TM synapse model). The dose-effect relationship can be described with a Hill function.

  • • Experimental data
  • ― Fit
  • - - Extrapolated