After we validated the Schaffer collaterals at neuron and synapse level, we validated them at network level. In particular, we reproduced one of the experiments reported in Sasaki et al. (2006), where Schaffer collaterals are stimulated at different intensities with and without Gabazine (an antagonist of GABAA receptors). As in the experiment, the feedforward inhibition linearises the I-O response, while the I-O response saturates quickly when the inhibition is blocked. We repeated the simulations over three different slices.
M-type (12)
E-type
Simulation and slice seed (5)
Stimulus percent (11)
Max SC (1)
Inhibition (2)