Experimental Data

Connection Anatomy

We collected and organized data on the local connectivity of pairs of pre- and postsynaptic morphological types (m-types). We used a subset of the data to constrain the connectome (the set of connections), namely bouton density and number of synapses per connection, and the rest to validate it.

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Bouton density
Syn./Conn.
Conn. Probability
Syn. Divergence
Syn. Divergence over E/I
Syn. Divergence/layer
Bouton density

Synaptic boutons, or simply, boutons, are enlargements of the axon, visible with light microscopy, that represent putative synaptic contacts. Bouton density is normally expressed as the number of boutons per 100 μm or per μm.

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Number of synapses per connection

Each connection between pairs of morphological types could include one or multiple synapses, which in part affects the strength of the connection.

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Connection probability

Connection probability is the number of connected pairs among all the tested pairs. Available experimental data suffers from at least two important limitations. First, the data often come from slice experiments where a subset of connections may have been cut. Second, the method usually does not report precise distance of the pairs and this does not allow an accurate replica in the model.

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Synapse divergence per presynaptic type

Synapse divergence or outdegree is the number of synapses made by a presynaptic neuron or neuron type.

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Percentage of synapse divergence onto pyramidal cells and interneurons

We can express the synapse divergence also in relation to the postsynaptic target. Here, we calculate the percentage of synapses made by a morphological type onto pyramidal cells or interneurons.

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Percentage of synapse divergence per layer

We present here the distribution of synapse divergence per morphological type across the different layers.

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